Two sample MR report

Telomere_length against aparc-a2009s rh area G-cingul-Post-ventral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0385204	0.0994058	0.7022812
Weighted median	23	-0.0185452	0.0570172	0.7449872
Inverse variance weighted	23	0.0001306	0.0388454	0.9973171
Simple mode	23	-0.0764686	0.1000644	0.4528710
Weighted mode	23	-0.0336469	0.0754943	0.6601780

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.87332	21	0.7187563
Inverse variance weighted	17.05175	22	0.7604993

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0023732	0.0056182	0.6770211

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005167	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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