Two sample MR report

Telomere_length against aparc-a2009s rh area G-cingul-Post-dorsal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1300823	0.1326923	0.3380831
Weighted median	23	0.0667614	0.0552953	0.2272932
Inverse variance weighted	23	-0.0103334	0.0522300	0.8431666
Simple mode	23	0.0563762	0.0915524	0.5443581
Weighted mode	23	0.0844331	0.0587311	0.1646139

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.41885	21	0.0150626
Inverse variance weighted	39.77376	22	0.0114886

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0086215	0.0074995	0.2632279

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012072	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8