Two sample MR report

Telomere_length against aparc-a2009s rh area G+S-transv-frontopol

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.0075419 0.1055405 0.9437083
Weighted median 23 -0.0662029 0.0586784 0.2592221
Inverse variance weighted 23 -0.0737389 0.0409604 0.0718210
Simple mode 23 -0.0395972 0.1006735 0.6978666
Weighted mode 23 -0.0531453 0.0690346 0.4495852

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.67223 21 0.3092092
Inverse variance weighted 24.46132 22 0.3235210

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0049906 0.0059649 0.412201

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0008504 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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