Two sample MR report

Telomere_length against aparc-a2009s rh area G+S-subcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1770654	0.1032058	0.1009444
Weighted median	23	-0.1116580	0.0575852	0.0525006
Inverse variance weighted	23	-0.0900812	0.0401821	0.0249728
Simple mode	23	-0.1255487	0.1000119	0.2225266
Weighted mode	23	-0.1455896	0.0715684	0.0541546

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.63713	21	0.3636265
Inverse variance weighted	23.54087	22	0.3717476

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0053408	0.005833	0.3702571

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008763	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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