Two sample MR report

Telomere_length against aparc-a2009s rh area G+S-paracentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1123675	0.0994055	0.2710554
Weighted median	23	0.0637152	0.0572078	0.2653862
Inverse variance weighted	23	0.0295667	0.0388451	0.4465711
Simple mode	23	0.1272858	0.1023160	0.2265751
Weighted mode	23	0.0946352	0.0672068	0.1730705

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.16660	21	0.5744537
Inverse variance weighted	19.98547	22	0.5839489

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.005084	0.0056182	0.3757767

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006232	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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