Two sample MR report

Telomere_length against aparc-a2009s rh area G+S-occipital-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1229674	0.0997524	0.2313008
Weighted median	23	0.0871901	0.0554244	0.1156875
Inverse variance weighted	23	0.0737446	0.0388452	0.0576404
Simple mode	23	0.0935917	0.0886009	0.3022800
Weighted mode	23	0.0962191	0.0600848	0.1235536

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.14649	21	0.4500299
Inverse variance weighted	21.43587	22	0.4939587

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030223	0.0056378	0.5975403

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007587	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8