Two sample MR report

Telomere_length against aparc-a2009s rh area G+S-frontomargin

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2583417	0.1148607	0.0353577
Weighted median	23	-0.0264690	0.0591919	0.6547507
Inverse variance weighted	23	0.0108928	0.0492418	0.8249289
Simple mode	23	-0.0862534	0.0939663	0.3686160
Weighted mode	23	-0.0368864	0.0719615	0.6133500

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.03797	21	0.1390776
Inverse variance weighted	35.35145	22	0.0355902

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0151935	0.0064917	0.0292112

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010735	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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