Two sample MR report

Telomere_length against aparc-a2009s rh area G+S-cingul-Mid-Post

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0272877	0.1203154	0.8227711
Weighted median	23	-0.1127483	0.0602483	0.0612906
Inverse variance weighted	23	-0.0727230	0.0468189	0.1203556
Simple mode	23	-0.0471247	0.1008998	0.6450602
Weighted mode	23	-0.0915861	0.0729205	0.2223011

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.76485	21	0.0776616
Inverse variance weighted	31.95953	22	0.0780886

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0061407	0.0068	0.3767451

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010746	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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