Two sample MR report

Telomere_length against aparc-a2009s rh area G+S-cingul-Mid-Ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0213343	0.1198069	0.8603730
Weighted median	23	-0.0492363	0.0602458	0.4137813
Inverse variance weighted	23	-0.0574873	0.0462943	0.2143184
Simple mode	23	0.1295225	0.1201333	0.2926443
Weighted mode	23	-0.0545216	0.0754393	0.4774641

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.50509	21	0.0822983
Inverse variance weighted	31.24716	22	0.0911678

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0048396	0.0067712	0.4826426

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010132	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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