Two sample MR report

Telomere_length against aparc-a2009s rh area G+S-cingul-Ant

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.0045647 0.1255690 0.9713447
Weighted median 23 -0.1187348 0.0555034 0.0324168
Inverse variance weighted 23 -0.0596924 0.0482929 0.2164406
Simple mode 23 -0.1234245 0.0958275 0.2111338
Weighted mode 23 -0.1234245 0.0667988 0.0781358

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 33.50983 21 0.0408608
Inverse variance weighted 34.00300 22 0.0490897

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0039454 0.0070968 0.5841321

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0011018 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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