Two sample MR report

Telomere_length against aparc-a2009s rh area G-Ins-lg+S-cent-ins

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0597664	0.1356868	0.6640950
Weighted median	23	-0.0724027	0.0592864	0.2219968
Inverse variance weighted	23	-0.0148949	0.0519622	0.7743818
Simple mode	23	-0.0668325	0.1177950	0.5762118
Weighted mode	23	-0.0825259	0.0682205	0.2392350

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.12662	21	0.0094791
Inverse variance weighted	39.36710	22	0.0128050

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0027551	0.0076687	0.7229839

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011973	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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