Two sample MR report

Telomere_length against aparc-a2009s lh volume S-temporal-transverse

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2986499	0.1225925	0.0238381
Weighted median	23	-0.1438024	0.0572251	0.0119734
Inverse variance weighted	23	-0.0844095	0.0506641	0.0957010
Simple mode	23	-0.0626342	0.0937229	0.5108988
Weighted mode	23	-0.1381160	0.0606902	0.0329519

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.93622	21	0.0594264
Inverse variance weighted	37.41784	22	0.0212751

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0131544	0.0069287	0.0714517

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012768	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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