Two sample MR report

Telomere_length against aparc-a2009s lh volume S-temporal-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0103392	0.1174423	0.9306821
Weighted median	23	-0.0349086	0.0562959	0.5351978
Inverse variance weighted	23	-0.0102917	0.0448381	0.8184565
Simple mode	23	0.1219488	0.0962400	0.2183580
Weighted mode	23	-0.0309383	0.0688557	0.6575952

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.31158	21	0.1067197
Inverse variance weighted	29.31158	22	0.1361782

Test for directional horizontal pleiotropy

egger_intercept	se	pval
2.9e-06	0.0066375	0.9996539

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008903	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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