Two sample MR report

Telomere_length against aparc-a2009s lh volume S-temporal-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1092467	0.0994064	0.2842126
Weighted median	23	-0.0050857	0.0550801	0.9264338
Inverse variance weighted	23	0.0413538	0.0388454	0.2870689
Simple mode	23	-0.0069537	0.1090467	0.9497307
Weighted mode	23	-0.0262568	0.0546829	0.6358499

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.62991	21	0.6722891
Inverse variance weighted	20.33878	22	0.5618572

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0092468	0.0056182	0.1146769

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006506	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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