Two sample MR report

Telomere_length against aparc-a2009s lh volume S-subparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2199213	0.1185287	0.0776271
Weighted median	23	-0.0036265	0.0575876	0.9497871
Inverse variance weighted	23	0.0159810	0.0500374	0.7494384
Simple mode	23	0.0004957	0.0851882	0.9954098
Weighted mode	23	-0.0119054	0.0584623	0.8405052

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.85714	21	0.0948966
Inverse variance weighted	36.50393	22	0.0267954

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0144842	0.0066989	0.042296

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011112	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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