Two sample MR report

Telomere_length against aparc-a2009s lh volume S-suborbital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1404190	0.1044539	0.1931895
Weighted median	23	-0.0673020	0.0553519	0.2240249
Inverse variance weighted	23	-0.0074339	0.0416566	0.8583647
Simple mode	23	-0.0820396	0.0921918	0.3831585
Weighted mode	23	-0.0789597	0.0697119	0.2695521

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.18729	21	0.3340744
Inverse variance weighted	25.29958	22	0.2829642

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0081652	0.0059035	0.1811568

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007677	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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