Two sample MR report

Telomere_length against aparc-a2009s lh volume S-precentral-sup-part

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1171419	0.1077979	0.2894943
Weighted median	23	-0.0332008	0.0583445	0.5693242
Inverse variance weighted	23	-0.0248027	0.0419963	0.5547941
Simple mode	23	0.0138374	0.1040216	0.8953831
Weighted mode	23	-0.0567133	0.0690727	0.4204170

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.6956	21	0.2605883
Inverse variance weighted	25.7140	22	0.2641637

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0056696	0.0060925	0.3626405

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007916	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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