Two sample MR report

Telomere_length against aparc-a2009s lh volume S-precentral-inf-part

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0478390	0.0994059	0.6353158
Weighted median	23	-0.0380837	0.0562337	0.4982537
Inverse variance weighted	23	-0.0341990	0.0388455	0.3786500
Simple mode	23	-0.1013837	0.0955685	0.3002667
Weighted mode	23	-0.0462263	0.0710683	0.5221375

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.65287	21	0.7319215
Inverse variance weighted	16.67509	22	0.7810294

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0008375	0.0056182	0.882922

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005288	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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