Two sample MR report

Telomere_length against aparc-a2009s lh volume S-postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0231327	0.0994054	0.8182394
Weighted median	23	0.0575205	0.0571074	0.3138230
Inverse variance weighted	23	0.0052783	0.0388453	0.8919167
Simple mode	23	0.0608671	0.1023298	0.5580376
Weighted mode	23	0.0801071	0.0942432	0.4044787

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.58156	21	0.9225724
Inverse variance weighted	12.61963	22	0.9432298

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0010963	0.0056182	0.8471688

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000383	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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