Two sample MR report

Telomere_length against aparc-a2009s lh volume S-pericallosal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0010608	0.0994060	0.9915864
Weighted median	23	0.0598804	0.0540697	0.2680927
Inverse variance weighted	23	0.0206597	0.0388454	0.5948329
Simple mode	23	0.0416030	0.0918613	0.6550636
Weighted mode	23	0.0500658	0.0771905	0.5233101

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.78035	21	0.7243322
Inverse variance weighted	16.82622	22	0.7728785

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0012034	0.0056182	0.8324636

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005184	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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