Two sample MR report

Telomere_length against aparc-a2009s lh volume S-parieto-occipital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1536648	0.1009705	0.1429558
Weighted median	23	0.0129990	0.0585458	0.8242892
Inverse variance weighted	23	-0.0361898	0.0399890	0.3654687
Simple mode	23	-0.1124709	0.1080536	0.3092355
Weighted mode	23	-0.0168851	0.0790676	0.8328628

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.66644	21	0.4189451
Inverse variance weighted	23.31474	22	0.3841438

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0072129	0.0057066	0.2200945

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007328	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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