Two sample MR report

Telomere_length against aparc-a2009s lh volume S-orbital-med-olfact

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0260888	0.1154655	0.8234292
Weighted median	23	-0.0985993	0.0569004	0.0831242
Inverse variance weighted	23	-0.0656797	0.0448594	0.1431606
Simple mode	23	-0.1226895	0.0949608	0.2097645
Weighted mode	23	-0.0814777	0.0650352	0.2234226

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.33264	21	0.1309670
Inverse variance weighted	29.33845	22	0.1354492

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0056346	0.0065259	0.3976587

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009757	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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