Two sample MR report

Telomere_length against aparc-a2009s lh volume S-orbital-lateral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0593213	0.0994071	0.5570528
Weighted median	23	0.0406002	0.0571192	0.4772095
Inverse variance weighted	23	0.0249714	0.0388459	0.5203321
Simple mode	23	0.0005941	0.0998061	0.9953044
Weighted mode	23	0.0254003	0.0749560	0.7379212

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.97000	21	0.6509022
Inverse variance weighted	18.11092	22	0.6993921

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0021091	0.0056183	0.7111304

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005613	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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