Two sample MR report

Telomere_length against aparc-a2009s lh volume S-orbital-H-Shaped

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0588774	0.0994079	0.5599866
Weighted median	23	0.0300767	0.0582446	0.6055847
Inverse variance weighted	23	-0.0228145	0.0388461	0.5569982
Simple mode	23	-0.0845641	0.1045718	0.4273638
Weighted mode	23	-0.0188079	0.0704813	0.7920704

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.89215	21	0.5281012
Inverse variance weighted	20.04748	22	0.5800696

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0022143	0.0056183	0.6974708

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000618	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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