Two sample MR report

Telomere_length against aparc-a2009s lh volume S-oc-temp-med+Lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1783201	0.1052021	0.1048495
Weighted median	23	-0.0152405	0.0558755	0.7850390
Inverse variance weighted	23	0.0006087	0.0433072	0.9887853
Simple mode	23	0.0608174	0.1058818	0.5715316
Weighted mode	23	-0.0677352	0.0656264	0.3132231

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.52064	21	0.3168595
Inverse variance weighted	27.34454	22	0.1984316

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0109862	0.0059458	0.0787769

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008286	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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