Two sample MR report

Telomere_length against aparc-a2009s lh volume S-oc-temp-lat

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1881101	0.1232343	0.1418212
Weighted median	23	0.0281716	0.0565896	0.6186089
Inverse variance weighted	23	0.0132537	0.0496401	0.7894725
Simple mode	23	0.1108596	0.0906509	0.2342956
Weighted mode	23	0.0681281	0.0588367	0.2593138

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.27446	21	0.0549073
Inverse variance weighted	35.92624	22	0.0309234

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0107361	0.0069649	0.1381396

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010921	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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