Two sample MR report

Telomere_length against aparc-a2009s lh volume S-oc-sup+transversal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2240917	0.1036094	0.0422378
Weighted median	23	0.0434844	0.0581830	0.4548387
Inverse variance weighted	23	0.0255501	0.0455557	0.5748975
Simple mode	23	0.0017089	0.1108417	0.9878383
Weighted mode	23	0.0166914	0.0721042	0.8190740

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.81408	21	0.3539707
Inverse variance weighted	30.25774	22	0.1123332

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0153279	0.0058557	0.0160837

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00093	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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