Two sample MR report

Telomere_length against aparc-a2009s lh volume S-oc-middle+Lunatus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0023515	0.1187146	0.9843834
Weighted median	23	0.0376465	0.0586118	0.5206772
Inverse variance weighted	23	0.0321855	0.0454318	0.4786751
Simple mode	23	0.2028902	0.1036220	0.0630337
Weighted mode	23	0.0726819	0.0762637	0.3509270

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.95111	21	0.0929748
Inverse variance weighted	30.09358	22	0.1162076

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0021206	0.0067094	0.75508

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009327	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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