Two sample MR report

Telomere_length against aparc-a2009s lh volume S-intrapariet+P-trans

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1022485	0.0994050	0.3153679
Weighted median	23	-0.0375791	0.0571421	0.5107681
Inverse variance weighted	23	-0.0195494	0.0388452	0.6147789
Simple mode	23	0.0658813	0.1238843	0.6001960
Weighted mode	23	-0.1307913	0.0862240	0.1435361

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.49667	21	0.6173935
Inverse variance weighted	19.31353	22	0.6258960

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0050778	0.0056182	0.3763495

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000593	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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