Two sample MR report

Telomere_length against aparc-a2009s lh volume S-interm-prim-Jensen

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0470419	0.0994479	0.6410710
Weighted median	23	0.0336566	0.0547032	0.5383844
Inverse variance weighted	23	0.0114243	0.0388635	0.7687878
Simple mode	23	0.0466543	0.0829158	0.5793482
Weighted mode	23	0.0350306	0.0607650	0.5701335

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	8.686816	21	0.9914713
Inverse variance weighted	8.838210	22	0.9941338

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.002187	0.0056207	0.7011239

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0002705	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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