Two sample MR report

Telomere_length against aparc-a2009s lh volume S-front-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0453564	0.1005999	0.6567122
Weighted median	23	-0.1133830	0.0523883	0.0304430
Inverse variance weighted	23	-0.1155214	0.0389295	0.0030028
Simple mode	23	-0.1835683	0.0851284	0.0422505
Weighted mode	23	-0.1314963	0.0631527	0.0491639

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.50793	21	0.4283243
Inverse variance weighted	22.09594	22	0.4541746

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0043081	0.0056857	0.457041

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009376	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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