Two sample MR report

Telomere_length against aparc-a2009s lh volume S-front-middle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1061920	0.0994066	0.2975304
Weighted median	23	0.0000618	0.0537152	0.9990827
Inverse variance weighted	23	-0.0449273	0.0388457	0.2474523
Simple mode	23	-0.0383976	0.0921636	0.6809897
Weighted mode	23	-0.0227868	0.0613039	0.7136709

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.36033	21	0.8044471
Inverse variance weighted	18.08789	22	0.7007647

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0092787	0.0056182	0.1135055

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005887	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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