Two sample MR report

Telomere_length against aparc-a2009s lh volume S-front-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2049244	0.0994057	0.0518511
Weighted median	23	-0.0599186	0.0551558	0.2773235
Inverse variance weighted	23	-0.0086355	0.0406050	0.8315834
Simple mode	23	-0.0784546	0.1052002	0.4637042
Weighted mode	23	-0.0846767	0.0592067	0.1667128

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.43648	21	0.5571621
Inverse variance weighted	24.03834	22	0.3452227

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0120521	0.0056182	0.0437868

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007299	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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