Two sample MR report

Telomere_length against aparc-a2009s lh volume S-collat-transv-post

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0256675	0.0994058	0.7987594
Weighted median	23	0.0065970	0.0583832	0.9100343
Inverse variance weighted	23	0.0404961	0.0388451	0.2971792
Simple mode	23	0.0558634	0.1155918	0.6336705
Weighted mode	23	-0.0281962	0.0796743	0.7267880

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.81620	21	0.5969292
Inverse variance weighted	19.33906	22	0.6243087

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0040624	0.0056182	0.4776043

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000619	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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