Two sample MR report

Telomere_length against aparc-a2009s lh volume S-collat-transv-ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1967176	0.1031005	0.0701555
Weighted median	23	-0.1334510	0.0604788	0.0273438
Inverse variance weighted	23	-0.1910540	0.0393670	0.0000012
Simple mode	23	-0.1285648	0.1009191	0.2159793
Weighted mode	23	-0.1319955	0.0784236	0.1064932

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.59300	21	0.3660565
Inverse variance weighted	22.59683	22	0.4247856

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0003478	0.0058271	0.9529759

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014176	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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