Two sample MR report

Telomere_length against aparc-a2009s lh volume S-circular-insula-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0334730	0.1147989	0.7734689
Weighted median	23	0.0022921	0.0569642	0.9679040
Inverse variance weighted	23	-0.0030435	0.0439155	0.9447473
Simple mode	23	0.1610724	0.1092350	0.1545012
Weighted mode	23	-0.0065335	0.0766412	0.9328358

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.00753	21	0.1399378
Inverse variance weighted	28.11813	22	0.1717993

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0018684	0.0064881	0.7761966

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008522	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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