Two sample MR report

Telomere_length against aparc-a2009s lh volume S-circular-insula-ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0694896	0.1004148	0.4965024
Weighted median	23	-0.0259104	0.0553401	0.6396395
Inverse variance weighted	23	-0.0260421	0.0393008	0.5075646
Simple mode	23	-0.0336805	0.0975772	0.7332467
Weighted mode	23	-0.0309372	0.0673140	0.6503166

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.42821	21	0.4330745
Inverse variance weighted	22.51822	22	0.4293456

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0058657	0.0056753	0.3131012

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000696	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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