Two sample MR report

Telomere_length against aparc-a2009s lh volume S-cingul-Marginalis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1151240	0.1137379	0.3229701
Weighted median	23	-0.1023187	0.0570190	0.0727387
Inverse variance weighted	23	-0.0397745	0.0439565	0.3655395
Simple mode	23	-0.1422096	0.0999882	0.1689736
Weighted mode	23	-0.1630416	0.0857231	0.0703511

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.49289	21	0.1551279
Inverse variance weighted	28.17103	22	0.1700821

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0046265	0.0064283	0.4796372

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008853	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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