Two sample MR report

Telomere_length against aparc-a2009s lh volume S-central

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2037259	0.1364226	0.1502204
Weighted median	23	-0.0710478	0.0609576	0.2438057
Inverse variance weighted	23	-0.0545391	0.0538065	0.3107668
Simple mode	23	-0.1294547	0.1031971	0.2228463
Weighted mode	23	-0.0977781	0.0719884	0.1881519

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.55317	21	0.0084237
Inverse variance weighted	42.21154	22	0.0058923

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00916	0.0077103	0.2480855

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013388	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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