Two sample MR report

Telomere_length against aparc-a2009s lh volume S-calcarine

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0699982	0.1100917	0.5317643
Weighted median	23	-0.0009482	0.0592786	0.9872376
Inverse variance weighted	23	0.0016382	0.0425293	0.9692729
Simple mode	23	-0.1028699	0.1091152	0.3560402
Weighted mode	23	0.0352728	0.0924800	0.7065576

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.75820	21	0.2158192
Inverse variance weighted	26.37115	22	0.2360884

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0043985	0.0062221	0.4873948

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007991	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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