Two sample MR report

Telomere_length against aparc-a2009s lh volume Pole-temporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2135853	0.1459229	0.1580884
Weighted median	23	-0.0469642	0.0634483	0.4591813
Inverse variance weighted	23	-0.0777380	0.0570536	0.1730263
Simple mode	23	-0.0115783	0.1182680	0.9228992
Weighted mode	23	-0.0369973	0.0859941	0.6712128

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	45.25637	21	0.0016027
Inverse variance weighted	47.46073	22	0.0012776

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0083413	0.0082475	0.3233495

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015593	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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