Two sample MR report

Telomere_length against aparc-a2009s lh volume Pole-occipital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1121342	0.1497959	0.4624128
Weighted median	23	-0.0797567	0.0600850	0.1843771
Inverse variance weighted	23	-0.0779545	0.0572739	0.1734879
Simple mode	23	-0.1339648	0.0993583	0.1912809
Weighted mode	23	-0.0930797	0.0696276	0.1949412

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	47.68713	21	0.0007584
Inverse variance weighted	47.82666	22	0.0011436

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0020986	0.0084661	0.8066307

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015712	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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