Two sample MR report

Telomere_length against aparc-a2009s lh volume Lat-Fis-post

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0867725	0.1126774	0.4498194
Weighted median	23	-0.1109520	0.0607604	0.0678414
Inverse variance weighted	23	-0.0639386	0.0430686	0.1376562
Simple mode	23	-0.2064655	0.1038755	0.0594411
Weighted mode	23	-0.1671653	0.0861539	0.0652659

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.98218	21	0.1714438
Inverse variance weighted	27.04445	22	0.2095429

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.001402	0.0063683	0.8278779

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009016	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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