Two sample MR report

Telomere_length against aparc-a2009s lh volume Lat-Fis-ant-Vertical

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1321072	0.0994073	0.1981248
Weighted median	23	0.0269797	0.0570865	0.6364904
Inverse variance weighted	23	-0.0028268	0.0388461	0.9419902
Simple mode	23	0.0858934	0.0947520	0.3744891
Weighted mode	23	-0.1156691	0.0713168	0.1190686

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.13568	21	0.7028492
Inverse variance weighted	19.13184	22	0.6371738

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0079379	0.0056183	0.172349

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005799	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8