Two sample MR report

Telomere_length against aparc-a2009s lh volume Lat-Fis-ant-Horizont

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0174315	0.1268791	0.8920340
Weighted median	23	-0.0367731	0.0637900	0.5642965
Inverse variance weighted	23	0.0343695	0.0484668	0.4782410
Simple mode	23	-0.0494729	0.1132849	0.6665765
Weighted mode	23	-0.0530856	0.0837683	0.5327981

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.20713	21	0.0344312
Inverse variance weighted	34.24139	22	0.0464164

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00104	0.007171	0.8860704

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010613	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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