Two sample MR report

Telomere_length against aparc-a2009s lh volume G-temp-sup-Plan-tempo

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0289549	0.0994051	0.7736935
Weighted median	23	-0.0716446	0.0604530	0.2359666
Inverse variance weighted	23	-0.0843145	0.0388450	0.0299661
Simple mode	23	0.0302303	0.1102989	0.7865827
Weighted mode	23	0.0252546	0.0968675	0.7967385

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.67546	21	0.7875997
Inverse variance weighted	16.04150	22	0.8138207

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0033991	0.0056182	0.5516505

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006288	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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