Two sample MR report

Telomere_length against aparc-a2009s lh volume G-temp-sup-Plan-polar

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0757098	0.1158355	0.5204644
Weighted median	23	-0.0270378	0.0560726	0.6296686
Inverse variance weighted	23	-0.0181474	0.0445307	0.6836214
Simple mode	23	-0.0368995	0.0944302	0.6997331
Weighted mode	23	-0.0295620	0.0635930	0.6465981

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.51547	21	0.1261284
Inverse variance weighted	28.91122	22	0.1474131

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0035343	0.0065467	0.5949741

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008827	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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