Two sample MR report

Telomere_length against aparc-a2009s lh volume G-temp-sup-Lateral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0513188	0.1003498	0.6144069
Weighted median	23	-0.0546116	0.0527478	0.3005135
Inverse variance weighted	23	-0.0793624	0.0388453	0.0410489
Simple mode	23	-0.0367765	0.0822022	0.6589670
Weighted mode	23	-0.0575195	0.0615468	0.3601580

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.40055	21	0.4347273
Inverse variance weighted	21.49448	22	0.4903845

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0017219	0.0056715	0.7644211

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007777	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8