Two sample MR report

Telomere_length against aparc-a2009s lh volume G-temp-sup-G-T-transv

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1130920	0.1065415	0.3005264
Weighted median	23	-0.1034830	0.0576444	0.0726225
Inverse variance weighted	23	-0.0566057	0.0409965	0.1673576
Simple mode	23	-0.1725406	0.1047101	0.1136049
Weighted mode	23	-0.1043902	0.0670088	0.1335368

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.12310	21	0.2871322
Inverse variance weighted	24.50419	22	0.3213666

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0034682	0.0060214	0.5707515

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008069	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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