Two sample MR report

Telomere_length against aparc-a2009s lh volume G-temporal-middle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1771647	0.1017103	0.0961634
Weighted median	23	-0.0276914	0.0575782	0.6305626
Inverse variance weighted	23	0.0409536	0.0435623	0.3471580
Simple mode	23	0.1682546	0.1178186	0.1673115
Weighted mode	23	-0.0654608	0.0638944	0.3167265

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.98512	21	0.4003680
Inverse variance weighted	27.66748	22	0.1869643

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0133923	0.0057484	0.0298765

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000872	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8